Botox, Dysport, Xeomin: Comparing the top wrinkle relaxers

Botox, Dysport, Xeomin: Comparing the top wrinkle relaxers

Botox is the first thing that comes to mind when people think of injectable wrinkle relaxers. And why not, it has been FDA-approved for cosmetic procedures as far back as 2002 whereas Dysport was approved only in 2009 and Xeomin in 2011.

All three brands contain the same active component, botulinum toxin type A, but each has its own unique formulation. Their manufacturers claim the fastest and longest absorption without giving patients the extraterrestrial look. In essence, they operate the same way and are all safe and effective.

Some medical professionals prefer to stick to one brand while others switch from one to another depending on the situation. We’ve broken down their differences based on the following criteria:


Dysport contains the smallest molecules, which is why it has the fastest absorption rate among the three brands, taking effect within 1–2 days and peaking within 5–7 days. Botox starts working a couple days later than Dysport and takes full effect in 7–10 days. On the other hand, Xeomin has a more gradual onset, and begins to take effect about the same time as Botox and peaks at around two weeks.


Botox and Xeomin are comparable in terms of strength. Dysport, on the other hand, is less potent owing to its smaller molecules. One unit of Botox or Xeomin is equivalent to 2.5–3 units of Dysport. So if forehead lines require 10–25 units of Botox or Xeomin, they will need 30–75 units of Dysport.

Related article: Is Botox the solution to your confidence problems?


Toxin spread or diffusion determines the number of injection points needed, and based on scientific consensus, there are no significant differences among the three. However, some physicians say that Dysport tends to diffuse over a wider area, making it ideal for forehead wrinkles or crows feet. It may not be as effective as Botox or Xeomin though if you want a more targeted application.


Most doctors agree that all three brands last 3–6 months even though Dysport is known to have the earliest onset of action. One study claimed that Botox lasts longer than Dysport but some doctors were quick to disagree.

Related article: Botox lifts mood, not just drooping skin

Area of injection

Cosmetically, the three brands can be used effectively in different areas, including the forehead, side of the eyes, and between the eyebrows. However, only Botox has been approved for treating medical issues, such as underarm sweating, eyelid spasm, chronic migraine, and Bell’s palsy.

Protein content

By design, the active part of the toxin in Botox and Dysport is enclosed in protective proteins. In Xeomin, this active part loses its protective proteins because it undergoes an extra step of purification. That means it is less likely to form antibodies that could reduce its effectiveness, which translates to a decreased risk of an allergic reaction or natural resistance.


Botox, Dysport, and Xeomin are all sold per unit, and the prices for treatments that use each of these products vary. Generally, practitioners charge approximately the same for any of the these 3 products and picking the right product is based on what the practitioner and the patient feel works best for them.

Let our experienced Nurse Practitioners determine which wrinkle relaxer is best for your needs. Contact us today to schedule a consultation.